The valve located between the left ventricle and the aorta

The heart has four valves. The mitral valve, the tricuspid valve, the pulmonary valve and the aortic valve. The mitral and the tricuspid valves, also known as the atrioventricular valves, are located between the top chambers of the heart, the atria, and the lower chambers of the heart, the ventricles. The aortic and pulmonary valves, are located between the ventricles and the arteries that emerge from the heart. These valves are also known as the semilunar valves.

The heart valves regulate blood flowing through the heart. After the atria fill with blood, the mitral and tricuspid valves open to allow the blood to flow from the atria into the ventricles. When the ventricles contract, the mitral and tricuspid valves close while the blood is pumped outward through the pulmonary and aortic valves to the lungs and body.

Printable summary

Overview

The normal human heart contains 4 valves that regulate blood flow into and out of the heart. The aortic and pulmonic valves are known as the semilunar valves, whereas the tricuspid and mitral valves are referred to as the atrioventricular valves. All the valves are trileaflet, with the exception of the mitral valve, which has 2 leaflets. Cardiac valves are surrounded by fibrous tissue forming partial or complete valvular rings, or annuli. These annuli join the fibrous skeleton of the heart to anchor and support the valvular structures.

The aortic valve is located between the left ventricular outflow tract and the ascending aorta. The aortic valve is the cardiac centerpiece. Relative to the aorta, the mitral valve is located posterior and to the left, the tricuspid valve is located inferiorly and to the right, and both valves abut on the posteroinferior margins of the aortic root, albeit with the atrioventricular separating structures interposing between the root and the tricuspid valve. [1, 2]

In most cases, the orifices of the coronary arteries arise within the 2 anterior sinuses of Valsalva, usually positioned just below the sinotubular junction. [3, 4, 5]  However, arteries can occasionally be positioned superior relative to the sinotubular junction. As a result of the semilunar attachment of the aortic valvar leaflets, 3 triangular extensions of the left ventricular outflow tract reach the level of the sinotubular junction. [6]  These triangles are formed of thinned fibrous walls of the aorta between the expanded sinuses of Valsalva. Their most apical regions represent areas of potential communication with the pericardial space and, in the case of the triangle between the right and left coronary aortic leaflets, with the plane of tissue interposed between the aorta and anteriorly located sleeve-like subpulmonary infundibulum. The 2 interleaflet triangles bordering the noncoronary leaflet are also in fibrous continuity with the fibrous trigones, the mitral valve, and the membranous septum.

Embryology

Semilunar valve formation begins during the fourth week of gestation. At this time, opposing dextrosuperior and sinistroinferior endocardial cushions appear in the cephalad portion of the truncus arteriosus. Simultaneously, 2 additional intercalated endocardial cushions form, each located 90º from the aforementioned dextrosuperior and sinistroinferior endocardial cushions.

The dextrosuperior and sinistroinferior cushions fuse and, in doing so, form the truncal septum. The truncal septum undergoes a complex process of differentiation, eventually forming the right and left aortic valve cusps and 2 leaflets of the pulmonic valve. Of the 2 intercalated endocardial cushions, the right cushion eventually forms the posterior aortic valve cusp, whereas the left forms the anterior pulmonic valve leaflet. This occurs during the counterclockwise rotation and caudal shift of the conotruncus. During this time, the endocardial cushions also undergo dedifferentiation from a myosin-heavy chain to an alpha-smooth muscle actin phenotype, resulting in mature arterial valvular leaflets. The improper fusion or the incomplete dedifferentiation of the previously mentioned endocardial cushions is thought to be responsible for the formation of anatomically and structurally congenitally abnormal aortic valves. [7, 8, 9]

The following image is an overview of the transitions occurring in early heart development in amniotes (see the image below).

Within the right atrium, the atrioventricular node is located within the triangle of Koch. This important triangle is demarcated by the tendon of Todaro, the attachment of the septal leaflet of the tricuspid valve, and the orifice of the coronary sinus. The apex of this triangle is occupied by the atrioventricular component of the membranous septum. The atrioventricular node is located just inferior to the apex of the triangle adjacent to the membranous septum; therefore, the atrioventricular node is in close proximity to the subaortic region and membranous septum of the left ventricular outflow tract. This relationship explains the risk of developing complete heart block or conduction abnormality in patients who suffer from various pathologies involving the aortic valve. The atrioventricular node continues as the bundle of His, piercing the membranous septum and penetrating to the left through the central fibrous body, which runs superficially along the crest of the ventricular septum, giving rise to the fascicles of the left bundle branch. [10]

The triangle between the right and noncoronary sinus is in close proximity to the bundle of His as it courses through the central fibrous body just below the inferior margin of the membranous ventricular septum, which can be of clinical significance in patients with endocarditis. [11]

Gross Anatomy

Aortic root

The aortic root is the direct continuation of the left ventricular outflow tract. It is located to the right and posterior, relative to the subpulmonary infundibulum, with its posterior margin wedged between the orifice of the mitral valve and the muscular ventricular septum extending from the basal attachment of the aortic valvar leaflets within the left ventricle to their peripheral attachment at the level of the sinotubular junction. [12]  Approximately two thirds of the circumference of the lower part of the aortic root is connected to the muscular ventricular septum, with the remaining one third in fibrous continuity with the aortic leaflet of the mitral valve. Its components include the sinuses of Valsalva, the fibrous interleaflet triangles, and the valvar leaflets themselves.

Annulus

When defined literally, an “annulus” is no more than a little ring. The aortic valve annulus is a collagenous structure lying at the level of the junction of the aortic valve and the ventricular septum, usually a semilunar crownlike structure demarcated by the hinges of the leaflets. This serves to provide structural support to the aortic valve complex as it attaches to the aortic media distally and the membranous and muscular ventricular septum proximally and anteriorly. [13, 14]  The valvar leaflets are attached throughout the length of the root. Seen in 3 dimensions, therefore, the leaflets take the form of a 3-pronged coronet, with the hinges from the supporting ventricular structures forming the crownlike ring. The base of the crown is a virtual ring, formed by joining the basal attachment points of the leaflets within the left ventricle. This plane represents the inlet from the left ventricular outflow tract into the aortic root. The top of the crown is a true ring, the sinotubular junction, demarcated by the sinus ridge and the related sites of attachment of the peripheral zones of apposition between the aortic valve leaflets. It forms the outlet of the aortic root into the ascending aorta.  

Fibrous trigones

The larger part of the noncoronary leaflet of the valve, along with part of the left coronary leaflet, is in fibrous continuity with the aortic or anterior leaflet of the mitral valve, with the ends of this area of fibrous continuity being thickened to form the so-called fibrous trigones. These trigones anchor the aortic-mitral valvar unit to the roof of the left ventricle.

The interleaflet triangle located between the right coronary and noncoronary aortic leaflets is confluent with the membranous septum. Together, the membranous septum and the right fibrous trigone form the central fibrous body of the heart. This is the area within the heart where the membranous septum, the atrioventricular valves, and the aortic valve join in fibrous continuity.

The hinge of the septal leaflet of the tricuspid valve separates the membranous septum into its atrioventricular and interventricular components (see the image below).

This relationship is key to understanding the relationship between the aortic valve and the conduction system.

Cusps/Leaflets

The normal aortic valve is trifoliate, and their semilunar attachments have already been described. The 3 aortic valve cusps are aptly named for the sinuses that they overlie. The right and left cusps are usually equal in size, with the posterior cusp being slightly larger in two thirds of individuals; however, this has no clinical significance. Each cusp has 2 free edges, both shared with the adjacent cusps. At the center of each free edge is a small fibrous bulge named the nodule of Arantius. These nodules are located at the contact site of valve cusp closure. The rim of each valve cusp is slightly thicker than the cusp body and is known as the lunula. The lunulae of adjacent cusps slightly overlap each other at the time of valve closure, serving a role of increased valve support (see the image below).

The lunula can have fenestrations, most often located adjacent to the commissures; however, these are also not of clinical consequence. [15, 14]

Commissures

Each cusp is attached to the wall of the aorta by the outward edges of its semicircular border. The level at which this attachment occurs is known as the sinotubular junction and is the functional level of the aortic valve orifice. A line of demarcation known as the supraaortic ridge identifies the sinotubular junction. This "ridge" was originally described by Leonardo da Vinci and is essentially thickened aortic wall.

The small spaces between each cusp's attachment point are called the aortic valve commissures. The 3 commissures lie at the apex of the annulus and are equally spaced around the aortic trunk. The commissures are composed of collagenous fibers oriented in a radial fashion that penetrate into the aortic intima and are anchored in the media of the aorta. This microscopic configuration provides optimal support of valvular structures, with stress on the valve cusps being transmitted into the aortic wall. The commissure between the left and posterior cusp is located at the right posterior aspect of the aortic root, whereas the commissure between the right and noncoronary cusp is located at the right anterior aspect of the aortic root. [16]

Microscopic Anatomy

Valve cusps

The aortic valve cusps have 3 readily identifiable layers: (1) lamina fibrosa, (2) lamina spongiosa, and (3) lamina radialis. The lamina fibrosa is the widest layer and faces the aortic or arterial side of the valve cusp. The lamina radialis is the thinnest of the 3 layers and faces the ventricular side of the valve. The lamina spongiosa lies between the lamina fibrosa and lamina radialis. A thin layer of endothelial cells covers the entire cusp, which is smooth on the ventricular side and ridged on the arterial side.

The extracellular components of these layers are primarily composed of collagen fibers arranged in a honeycomblike structure that serves to preserve the geometry of the collagen fibers under the hemodynamic stresses that the valve apparatus encounters. [14, 10] Within the extracellular matrix of the leaflets lie interstitial cells that are similar to smooth muscle cells and fibroblasts and that have been termed myofibroblasts. These cells are supplied oxygen via diffusion and a microvascular network.

Pathophysiologic Variants

Unicuspid aortic valve

Unicuspid aortic valve is a congenital valvular defect with an incidence of 0.02% in the general population. It is commonly associated with clinically significant aortic stenosis, usually manifesting during the third decade of life. All valves are unicommissural with the posterior commissural attachment. The free edge of the valve extends from the single commissure without further communication with the aorta. An estimated 50% of individuals with unicuspid aortic valve have associated ascending aortic dilatation. This is a rare cardiac anomaly but should be suspected in patients presenting at a young age with clinically significant aortic stenosis. [15, 17, 18]

Bicuspid aortic valve

Bicuspid aortic valve is the most common congenital cardiac anomaly, occurring in 1-2% of the population, with a 2:1 male predominance. Evidence exists of familial clustering, with the incidence as high as 10% in some families. Bicuspid aortic valve may be clinically silent but can lead to early development of aortic stenosis or aortic insufficiency, most commonly in the fifth and sixth decades of life. Conditions associated with bicuspid aortic valve include patent ductus arteriosus, Williams syndrome, Turner syndrome, and coarctation of the aorta. Of clinical importance is the association of aortic root dilatation and ascending aortic aneurysm. [15, 19]

Quadricuspid aortic valve

Quadricuspid aortic valve (QAV), first described in 1862 by Balington, is a rare congenital valvular abnormality that affects both the pulmonic and aortic valves in a 10:1 ratio. The incidence of QAV is estimated at 0.0125–0.033% in the general population. It most commonly occurs as an isolated defect but has been associated with patent ductus arteriosus, Ehlers-Danlos syndrome, hypertrophic obstructive cardiomyopathy, and subaortic stenosis. Aortic valvular insufficiency is commonly observed in QAV. It occurs secondary to a central orifice formed from malcoaptation of the 4 valvular leaflets. In a small case series, 56% of subjects with QAV had significant valvular insufficiency, with a mean age at presentation of 46 years. [20, 21]

Lambl's excrescences

Lambl's excrescences are fine filamentous lesions of valvular leaflets. The incidence increases with age, and it is considered as a degenerative change on the surface of leaflets due to mechanical wear and tear. Aortic valve is commonly involved. Fine strands have acellular connective tissue cores with some elastic fibers. Multiple adjacent excrescences may stick together and grow up to large, complex form called "giant Lambl's excrescence." Whether the excrescences may serve as a nidus for bacterial growth or cause a systemic embolism is controversial. In echocardiography, it appears as very thin, delicate, lintlike mobile threads arising from the free borders or ventricular surfaces of aortic leaflets. It may be multiple and several centimeters long. Improving image quality increases identification of this lesion. The echocardiographic significance of Lambl's excrescences lies in the differential diagnosis from the vegetation of infective endocarditis. [1]

Papillary fibroelastoma

Papillary fibroelastoma is a benign avascular tumor arising from the normal endocardium. It can occur anywhere in the heart, but most frequently arises from valvular endocardium. Most papillary fibroelastomas are found in elderly; it may be a hamartoma that develops in a degenerative wear-and-tear process. Characteristic numerous gelatinous papillary fronds of tumor surface consist of dense connective tissue core covered by endothelium. On echocardiography, a small mobile tumor with fine frond-like surface attaches to the downstream side of the valve by a small stalk. Surgical resection is needed because it may cause a systemic embolism. [2]

1. Aziz F, Baciewicz FA., Jr. Lambl's excrescences: review and recommendations. Tex Heart Inst J. 2007. 34:366–368. [QxMD MEDLINE Link].

2. Klarich KW, Enriquez-Sarano M, Gura GM, Edwards WD, Tajik AJ, Seward JB. Papillary fibroelastoma: echocardiographic characteristics for diagnosis and pathologic correlation. J Am Coll Cardiol. 1997. 30:784–790. [QxMD MEDLINE Link].

3. Reid K. The anatomy of the sinus of Valsalva. Thorax. 1970. 25:79–85. [QxMD MEDLINE Link].

4. Turner K, Navartnam V. The positions of coronary arterial ostia. Clin Anat. 1996. 9:376–380. [QxMD MEDLINE Link].

5. Muriago M, Sheppard MN, Ho SY, Anderson RH. Location of the coronary arterial orifices in the normal heart. Clin Anat. 1997. 10:297-302. [QxMD MEDLINE Link].

6. Sutton JP III, Ho SY, Anderson RH. The forgotten interleaflet triangles: a review of the surgical anatomy of the aortic valve. Ann Thorac Surg. 1995. 59:419-427. [QxMD MEDLINE Link].

7. Anderson RH, Webb S, Brown NA, Lamers W, Moorman A. Development of the heart: (3) formation of the ventricular outflow tracts, arterial valves, and intrapericardial arterial trunks. Heart. 2003 Sep. 89(9):1110-8. [QxMD MEDLINE Link].

8. Hurwitz LE, Roberts WC. Quadricuspid semilunar valve. Am J Cardiol. 1973 May. 31(5):623-6. [QxMD MEDLINE Link].

9. Restivo A, Piacentini G, Placidi S, Saffirio C, Marino B. Cardiac outflow tract: a review of some embryogenetic aspects of the conotruncal region of the heart. Anat Rec A Discov Mol Cell Evol Biol. 2006 Sep. 288(9):936-43. [QxMD MEDLINE Link].

10. Nicoló Piazza, MD, Peter de Jaegere, MD, PhD, Carl Schultz, et al. Anatomy of the Aortic Valvar Complex and Its Implications for Transcatheter Implantation of the Aortic Valve. Circulation. 2008. 10-116:71-81. [QxMD MEDLINE Link].

11. Yacoub MH, Kilner PJ, Birks EJ, Misfeld M. The aortic outflow and root: a tale of dynamism and crosstalk. Ann Thorac Surg. 1999. 68:S37-43. [QxMD MEDLINE Link].

12. Anderson RH. Clinical anatomy of the aortic root. Heart. Dec 2000. 8 (6):670–673. [QxMD MEDLINE Link].

13. Hamdan A, Guetta V, Konen E, Goitein O, Segev A, Raanani E, et al. Deformation dynamics and mechanical properties of the aortic annulus by 4-dimensional computed tomography: insights into the functional anatomy of the aortic valve complex and implications for transcatheter aortic valve therapy. J Am Coll Cardiol. 2012 Jan 10. 59(2):119-27. [QxMD MEDLINE Link].

14. Misfeld M, Sievers HH. Heart valve macro- and microstructure. Philos Trans R Soc Lond B Biol Sci. 2007 Aug 29. 362(1484):1421-36. [QxMD MEDLINE Link]. [Full Text].

15. Malouf JF, Edwards WD, Tajik AJ, Seward J. Functional anatomy of the heart. Fuster V, O’Rourke RA, Walsh RA, Poole-Wilson P, eds. Hurst’s The Heart. 12th ed. New York, NY: McGraw-Hill Companies, Inc; 2008.

16. Iskandar A, Thompson PD. A meta-analysis of aortic root size in elite athletes. Circulation. 2013 Feb 19. 127(7):791-8. [QxMD MEDLINE Link].

17. Novaro GM, Mishra M, Griffin BP. Incidence and echocardiographic features of congenital unicuspid aortic valve in an adult population. J Heart Valve Dis. 2003 Nov. 12(6):674-8. [QxMD MEDLINE Link].

18. Ren XS, Aggarwal K, Balentine J, et al. Aortic stenosis. Medscape Reference. June 22, 2011. [Full Text].

19. Warnes CA. Bicuspid aortic valve and coarctation: two villains part of a diffuse problem. Heart. 2003 Sep. 89(9):965-6. [QxMD MEDLINE Link]. [Full Text].

20. Holt NF, Sivarajan M, Mandapati D, Printsev Y, Elefteriades JA. Quadricuspid aortic valve with aortic insufficiency: case report and review of the literature. J Card Surg. 2007 May-Jun. 22(3):235-7. [QxMD MEDLINE Link].

21. Feldman BJ, Khandheria BK, Warnes CA, Seward JB, Taylor CL, Tajik AJ. Incidence, description and functional assessment of isolated quadricuspid aortic valves. Am J Cardiol. 1990 Apr 1. 65(13):937-8. [QxMD MEDLINE Link].

22. Anderson RH. Clinical anatomy of the aortic root. Heart. 2000 Dec. 84(6):670-3. [QxMD MEDLINE Link]. [Full Text].

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