Over the counter antihistamines for high blood pressure

Over the counter antihistamines for high blood pressure

There are non-prescription drugs that can be used safely if you have high blood pressure. A common problem with these drugs is that they may contain more than one medication. It is important to look at the ingredients to see what is included in each product.

Many people find relief of allergy symptoms by taking antihistamines. These include:

  • diphenhydramine
  • chlorpheniramine
  • hydroxyzine

They can cause drowsiness, so be careful if driving or at work. Newer antihistamines like loratadine and certirizine cause less drowsiness.

Decongestants are also available without a prescription. The most common decongestants are:

  • pseudoephedrine
  • phenylephrine

You should avoid these if you have high blood pressure, especially if your blood pressure has been difficult to control. If you have high blood pressure, check the ingredients of all over-the-counter allergy products to be sure they do not contain pseudoephedrine or phenylephrine.

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Several types of medications are used to treat allergy symptoms. Here's more information.

By Mayo Clinic Staff

Allergy medications are available as pills, liquids, inhalers, nasal sprays, eyedrops, skin creams and shots (injections). Some are available over-the-counter; others are available by prescription only. Here's a summary of the types of allergy medications and why they're used.

Antihistamines

Antihistamines block histamine, a symptom-causing chemical released by your immune system during an allergic reaction.

Pills and liquids

Oral antihistamines are available over-the-counter and by prescription. They ease a runny nose, itchy or watery eyes, hives, swelling, and other signs or symptoms of allergies. Because some of these drugs can make you feel drowsy and tired, take them with caution when you need to drive or do other activities that require alertness.

Antihistamines that tend to cause drowsiness include:

  • Diphenhydramine
  • Chlorpheniramine

These antihistamines are much less likely to cause drowsiness:

  • Cetirizine (Zyrtec, Zyrtec Allergy)
  • Desloratadine (Clarinex)
  • Fexofenadine (Allegra, Allegra Allergy)
  • Levocetirizine (Xyzal, Xyzal Allergy)
  • Loratadine (Alavert, Claritin)

Nasal sprays

Antihistamine nasal sprays help relieve sneezing, itchy or runny nose, sinus congestion, and postnasal drip. Side effects of antihistamine nasal sprays might include a bitter taste, drowsiness or feeling tired. Prescription antihistamine nasal sprays include:

  • Azelastine (Astelin, Astepro)
  • Olopatadine (Patanase)

Eyedrops

Antihistamine eyedrops, available over-the-counter or by prescription, can ease itchy, red, swollen eyes. These drops might have a combination of antihistamines and other medicines.

Side effects might include headache and dry eyes. If antihistamine drops sting or burn, try keeping them in the refrigerator or using refrigerated artificial-tear drops before you use them. Examples include:

  • Ketotifen (Alaway, Zaditor)
  • Olopatadine (Pataday, Patanol, Pazeo)
  • Pheniramine and naphazoline (Visine, Opcon-A, others)

Decongestants

Decongestants are used for quick, temporary relief of nasal and sinus congestion. They can cause trouble sleeping, headache, increased blood pressure and irritability. They're not recommended for people with high blood pressure, cardiovascular disease, glaucoma or hyperthyroidism.

Pills and liquids

Oral decongestants relieve nasal and sinus congestion caused by hay fever (allergic rhinitis). Many decongestants, such as pseudoephedrine (Sudafed), are available over-the-counter.

A number of oral allergy medications contain a decongestant and an antihistamine. Examples include:

  • Cetirizine and pseudoephedrine (Zyrtec-D 12 Hour)
  • Desloratadine and pseudoephedrine (Clarinex-D)
  • Fexofenadine and pseudoephedrine (Allegra-D)
  • Loratadine and pseudoephedrine (Claritin-D)

Nasal sprays and drops

Nasal decongestant sprays and drops relieve nasal and sinus congestion if used only for a short time. Repeated use of these drugs for more than three consecutive days may result in a cycle where congestion recurs or gets worse. Examples include:

  • Oxymetazoline (Afrin)
  • Tetrahydrozoline (Tyzine)

Corticosteroids

Corticosteroids relieve symptoms by suppressing allergy-related inflammation.

Nasal sprays

Corticosteroid sprays prevent and relieve stuffiness, sneezing and runny nose. Side effects can include an unpleasant taste, nasal irritation and nosebleeds. Examples include:

  • Budesonide (Rhinocort)
  • Fluticasone furoate (Flonase Sensimist)
  • Fluticasone propionate (Flonase Allergy Relief)
  • Mometasone (Nasonex)
  • Triamcinolone (Nasacort Allergy 24 Hour)

For people who are bothered by the feeling of liquid running down their throats or the unpleasant taste of these sprays, there are two aerosol formulas:

  • Beclomethasone (Qnasl)
  • Ciclesonide (Zetonna)

Inhalers

Inhaled corticosteroids are often used daily as part of treatment for asthma caused or complicated by reactions to airborne allergy triggers (allergens). Side effects are generally minor and can include mouth and throat irritation and oral yeast infections.

Some inhalers combine corticosteroids with long-acting bronchodilators. Prescription inhalers include:

  • Beclomethasone (Qvar Redihaler)
  • Budesonide (Pulmicort Flexhaler)
  • Ciclesonide (Alvesco)
  • Fluticasone (Flovent)
  • Mometasone (Asmanex Twisthaler)

Eyedrops

Corticosteroid eyedrops are used to relieve persistent itchy, red or watery eyes when other interventions aren't effective. A physician specializing in eye disorders (ophthalmologist) usually monitors the use of these drops because of the risk of problems, such as cataracts, glaucoma and infection. Examples include:

  • Fluorometholone (Flarex, FML)
  • Loteprednol (Alrex, Lotemax)
  • Prednisolone (Omnipred, Pred Forte, others)

Pills and liquids

Oral corticosteroids are used to treat severe symptoms caused by all types of allergic reactions. Long-term use can cause cataracts, osteoporosis, muscle weakness, stomach ulcers, increased blood sugar (glucose) and delayed growth in children. Oral corticosteroids can also worsen high blood pressure.

Prescription oral corticosteroids include:

  • Prednisolone (Prelone)
  • Prednisone (Prednisone Intensol, Rayos)
  • Methylprednisolone (Medrol)

Skin creams

Corticosteroid creams relieve allergic skin reactions such as itching, redness or scaling. Some low-potency corticosteroid creams are available without a prescription, but talk to your doctor before using these drugs for more than a few weeks.

Side effects can include skin discoloration and irritation. Long-term use, especially of stronger prescription corticosteroids, can cause thinning of the skin and abnormal hormone levels. Examples include:

  • Betamethasone (Dermabet, Diprolene, others)
  • Desonide (Desonate, DesOwen)
  • Hydrocortisone (Locoid, Micort-HC, others)
  • Mometasone (Elocon)
  • Triamcinolone

Mast cell stabilizers

Mast cell stabilizers block the release of chemicals in the immune system that contribute to allergic reactions. These drugs are generally safe but usually need to be used for several days to produce the full effect. They're usually used when antihistamines are not working or not well-tolerated.

Nasal spray

Over-the-counter nasal sprays include cromolyn (Nasalcrom).

Eyedrops

Prescription eyedrops include the following:

  • Cromolyn (Crolom)
  • Lodoxamide (Alomide)
  • Nedocromil (Alocril)

Leukotriene inhibitors

A leukotriene inhibitor is a prescription medication that blocks symptom-causing chemicals called leukotrienes. This oral medication relieves allergy signs and symptoms including nasal congestion, runny nose and sneezing. Only one type of this drug, montelukast (Singulair), is approved for treating hay fever.

In some people, leukotriene inhibitors can cause psychological symptoms such as anxiety, depression, strange dreams, trouble sleeping, and suicidal thinking or behavior.

Allergen immunotherapy

Immunotherapy is carefully timed and gradually increased exposure to allergens, particularly those that are difficult to avoid, such as pollens, dust mites and molds. The goal is to train the body's immune system not to react to these allergens.

Immunotherapy might be used when other treatments aren't effective or tolerated. It is also helpful in reducing asthma symptoms in some patients.

Shots

Immunotherapy may be given as a series of injections, usually one or two times a week. The dose may be increased weekly or every two weeks based on the patient's tolerance. Injections of the maximum tolerated dose may then be given every two to four weeks year round.

Side effects might include irritation at the injection site and allergy symptoms such as sneezing, congestion or hives. Rarely, allergy shots can cause anaphylaxis, a sudden life-threatening reaction that causes swelling in the throat, difficulty breathing, and other signs and symptoms.

Sublingual immunotherapy (SLIT)

With this type of immunotherapy, you place an allergen-based tablet under your tongue (sublingual) and allow it to be absorbed. This treatment has been shown to reduce runny nose, congestion, eye irritation and other symptoms associated with hay fever. It also improves asthma symptoms.

One SLIT tablet contains dust mites (Odactra). Several SLIT tablets contain extracts from pollens of different types of grass, including the following:

  • Short ragweed (Ragwitek)
  • Sweet vernal, orchard, perennial rye, Timothy and Kentucky blue grass (Oralair)
  • Timothy grass (Grastek)

Biological medications

Some medications target a specific reaction in the immune system and try to prevent it from happening. These medications are given as injections. They include dupilumab (Dupixent) to treat allergic skin reactions and omalizumab (Xolair) to treat asthma or hives when other medications don't help.

Side effects of biological medications may include redness, itchiness, or irritation of the eyes and irritation at the injection site.

Emergency epinephrine shots

Epinephrine shots are used to treat anaphylaxis, a sudden, life-threatening reaction. The drug is administered with a self-injecting syringe and needle device (auto-injector). You might need to carry two auto-injectors if there's a chance you could have a severe allergic reaction to a certain food, such as peanuts, or if you're allergic to bee or wasp venom.

A second injection is sometimes needed. As a result, it's important to call 911 or get immediate emergency medical care.

A health care professional will train you on how to use an epinephrine auto-injector. It's important to get the type that your doctor prescribes, as the method for injection may differ slightly for each brand. Also, be sure to replace your emergency epinephrine before the expiration date.

Examples of these medications include:

  • Adrenaclick
  • Auvi-Q
  • EpiPen
  • EpiPen Jr

Get your doctor's advice

Work with your doctor to choose the most effective allergy medications and avoid problems. Even over-the-counter allergy medications have side effects, and some allergy medications can cause problems when combined with other medications.

It's especially important to talk to your doctor about taking allergy medications in the following circumstances:

  • You're pregnant or breast-feeding.
  • You have a chronic health condition, such as diabetes, glaucoma, osteoporosis or high blood pressure.
  • You're taking other medications, including herbal supplements.
  • You're treating allergies in a child. Children need different doses of medication or different medications from adults.
  • You're treating allergies in an older adult. Some allergy medications can cause confusion, urinary tract symptoms or other side effects in older adults.
  • You're already taking an allergy medication that isn't working. Bring the medication with you in its original bottle or package when you see your doctor.

Keep track of your symptoms, when you use your medications and how much you use. This will help your doctor figure out what works best. You might need to try a few medications to determine which are most effective and have the least bothersome side effects for you.

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March 05, 2022

  1. Allergy meds could affect your driving. U.S. Food and Drug Administration. https://www.fda.gov/consumers/consumer-updates/allergy-meds-could-affect-your-driving. Accessed Feb. 8, 2020.
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  6. Hamrah P, et al. Allergic conjuctivitis: Management. https://www.uptodate.com/contents/search. Accessed March 3, 2017.
  7. Weston WL, et al. Treatment of atopic dermatitis (eczema). https://www.uptodate.com/contents/search. Accessed Feb. 8, 2020.
  8. AskMayoExpert, Allergy immunotherapy. Mayo Clinic; 2019.
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See more In-depth

See also

  1. Allergies
  2. Allergies and asthma
  3. Allergy education
  4. Allergy skin tests
  5. Allergy-proof your home
  6. Anaphylaxis
  7. Anaphylaxis: First aid
  8. Aspirin allergy
  9. Atopic dermatitis (eczema)
  10. Atopic dermatitis: 6 ways to manage itchy skin
  11. Atopic dermatitis: Proper bathing can reduce itching
  12. Atopic dermatitis: Understand your triggers
  13. Avoid rebound nasal congestion
  14. Bradycardia
  15. Breastfeeding and medications
  16. Can baby eczema be prevented?
  17. Can I exercise if I have atopic dermatitis?
  18. Cough
  19. COVID-19, cold, allergies and the flu
  20. Dermatitis
  21. Does honey offer sweet relief for allergies?
  22. Drug allergy
  23. Ease stress to reduce eczema symptoms
  24. Eczema bleach bath: Can it improve my symptoms?
  25. Food allergy
  26. Food allergy or intolerance?
  27. Hay fever
  28. Hay fever: How to avoid triggers
  29. Hives and angioedema
  30. Honey: An effective cough remedy?
  31. How to treat baby eczema
  32. I have atopic dermatitis. How can I sleep better?
  33. Living better with atopic dermatitis (eczema)
  34. Nasal Cleaning
  35. Nasal congestion
  36. Nasal spray addiction: Is it real?
  37. Nausea and vomiting
  38. Ozone air purifiers
  39. Peeling skin
  40. Prednisone risks, benefits
  41. Prednisone withdrawal: Why taper down slowly?
  42. Runny nose
  43. Seasonal allergies
  44. Shortness of breath
  45. Common skin rashes
  46. Types of dermatitis
  47. Stung by a Plant
  48. Sulfa allergy
  49. Tachycardia
  50. Allergy tests
  51. Watery eyes
  52. Wheezing
  53. White patch on skin: A cause for concern?

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Can a person with high blood pressure take antihistamine?

Antihistamines are the most common medication for allergies. Most of them seem to be safe if you have high blood pressure -- but again, ask to make sure. Don't take decongestants unless your doctor tells you otherwise. They may raise your blood pressure.

Can I take Claritin if I have high blood pressure?

However, medicines containing decongestants — including Allegra-D, Zyrtec-D and Claritin-D — could increase your blood pressure and heart rate or interfere with your heart medication.

Can Benadryl help with high blood pressure?

But because diphenhydramine has an atropine-like action, it may lower your blood pressure, and caution should be taken if you have hypertension (high blood pressure) and take medication.

Does Claritin 24 raise blood pressure?

Claritin. Claritin is a brand name for the drug loratadine, which doesn't usually raise blood pressure. Claritin-D, a combination of loratadine and pseudoephedrine, can elevate blood pressure.