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DescriptionsIbuprofen and acetaminophen combination is used to relieve minor aches and pains including headache, backache, toothache, menstrual cramps, muscle aches, or arthritis pain. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used in this combination to relieve inflammation, swelling, and pain. Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time. But acetaminophen may cause other unwanted effects when taken in large doses, including serious liver damage. This medicine is available as an over-the-counter (OTC) product. Portions of this document last updated: June 01, 2022 Copyright © 2022 IBM Watson Health. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. . Tylenol
(acetaminophen) and Motrin (ibuprofen) are
pain relievers and fever reducers used for treating pain and fever associated with many conditions. Motrin is also used to treat inflammatory conditions such as
arthritis. The drugs belong to different drug classes. Tylenol is an analgesic (pain reliever) and
antipyretic and Motrin is a nonsteroidal anti-inflammatory drug (NSAID). Side effects of Tylenol and Motrin that are similar include nausea, stomach pain, skin itching or rash, and headache. What Are Possible Side Effects of Ibuprofen?Common side effects of Ibuprofen include:
Other side effects of Motrin may occur. Consult your physician if you experience any possible side effects of Motrin. What Are Possible Side Effects of Acetaminophen?Common side effects of Acetaminophen include:
Get medical help right away if you notice symptoms of a rare serious allergic reaction to Tylenol, including:
What Is Ibuprofen?Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) indicated for relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis, for relief of mild to moderate pain, and for treatment of primary dysmenorrhea. A generic formulation is available. What Is Acetaminophen?Acetaminophen temporarily relieves minor aches and pains due to: the common cold, headache, backache, minor pain of arthritis, toothache, premenstrual and menstrual cramps, and temporarily reduces fever. QUESTIONMedically speaking, the term "myalgia" refers to what type of pain? See AnswerWhat Drugs Interact With Ibuprofen?Ibuprofen may interact with other drugs. Tell your doctor all medications and supplements you use. What Drugs Interact With Acetaminophen?Tylenol may interact with aspirin or other NSAIDs and blood pressure medications. Tylenol may also interact with antibiotics, antifungals, sulfa drugs, tuberculosis medicines, birth control pills or hormone replacement therapy, cancer medications, cholesterol-lowering medications, gout or arthritis medications (including gold injections), HIV/AIDS medications, medicines to treat psychiatric disorders, or seizure medications. How Should Ibuprofen Be Taken?The recommended dose of Motrin should be adjusted to suit individual patients needs but should not exceed 3200 mg in the total daily dose. Use of alcohol and smoking could increase side effects. Safe use of Motrin for use by children has not been established. It is not known whether ibuprofen is harmful to an unborn baby. How Should Acetaminophen Be Taken?Do not take more than directed. Liver warning: This product contains acetaminophen. Severe liver damage may occur if:
Do not use
Stop use and ask a doctor if
These could be signs of a serious condition. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. Ask a doctor before use if the user has liver disease Ask a doctor or pharmacist before use if the user is taking blood thinning drug warfarin. SLIDESHOWBack Pain: 16 Back Pain Truths and Myths See SlideshowFromDisclaimer All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA). Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph. Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs. The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site. As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current. Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice. If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information. You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088. References RxList. Motrin Product Monograph. What is the difference between Tylenol and ibuprofen?While acetaminophen only works in the brain, ibuprofen works in the brain and the rest of the body. This means acetaminophen only helps reduce pain and fever, while ibuprofen has the added benefit of reducing inflammation and swelling at the site of an injury.
Is Tylenol stronger or ibuprofen?Ibuprofen is more effective than acetaminophen for treating inflammatory pain conditions. Ibuprofen is FDA-approved to treat osteoarthritis and rheumatoid arthritis, whereas acetaminophen may be used off-label for these conditions. However, acetaminophen may cause less serious side effects than ibuprofen.
Is Tylenol just ibuprofen?Tylenol, Advil, and Aleve are common pain relievers on drugstore shelves. While all three medications can help alleviate a child's discomfort, the active ingredient in each drug is different. In Tylenol, it's acetaminophen; in Advil and Motrin, it's ibuprofen; and in Aleve, it is naproxen.
Why do doctors recommend Tylenol over ibuprofen?“Too much ibuprofen can cause long-term kidney complications and potentially liver complications, too. It can also cause painful and bleeding ulcers in the stomach. Acetaminophen can be hard on the liver and may also cause kidney problems with long-term, chronic use,” Reeder says.
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